Download PDF by B. E. Maryanoff,A. B. Reitz: Advances in Medicinal Chemistry: 4

By B. E. Maryanoff,A. B. Reitz

ISBN-10: 0444546499

ISBN-13: 9780444546494

ISBN-10: 0762300647

ISBN-13: 9780762300648

quantity four of Advances in Medicinal Chemistry is constituted of six chapters on a variety of subject matters in medicinal chemistry, together with molecular modeling, structure-based drug layout, natural synthesis, peptide conformational research, organic evaluate, structure-activity correlation, and lead optimization. bankruptcy 1 provides an account approximately amino acid-based peptide mimetics equivalent to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. bankruptcy 2 addresses new aspects of the medicinal chemistry of the $64000 anticancer drug Taxol® (paclitaxel). bankruptcy three relates an account of the quest for brand spanking new medications for the therapy of malaria in line with the normal product artemisinin. bankruptcy four applies computational chemistry to the assessment of compound libraries for organic checking out. bankruptcy five describes the development of a three-dimensional molecular version of the human thrombin receptor, the 1st protease-activated G-protein coupled receptor (PAR-1), as a way to discover the intermolecular contacts interested in agonist peptide reputation. ultimately, bankruptcy 6 describes the study performed at Merck on inhibitors of farnesyl transferase as a possible therapy for human cancers.

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By B. E. Maryanoff,A. B. Reitz

ISBN-10: 0444546499

ISBN-13: 9780444546494

ISBN-10: 0762300647

ISBN-13: 9780762300648

quantity four of Advances in Medicinal Chemistry is constituted of six chapters on a variety of subject matters in medicinal chemistry, together with molecular modeling, structure-based drug layout, natural synthesis, peptide conformational research, organic evaluate, structure-activity correlation, and lead optimization. bankruptcy 1 provides an account approximately amino acid-based peptide mimetics equivalent to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. bankruptcy 2 addresses new aspects of the medicinal chemistry of the $64000 anticancer drug Taxol® (paclitaxel). bankruptcy three relates an account of the quest for brand spanking new medications for the therapy of malaria in line with the normal product artemisinin. bankruptcy four applies computational chemistry to the assessment of compound libraries for organic checking out. bankruptcy five describes the development of a three-dimensional molecular version of the human thrombin receptor, the 1st protease-activated G-protein coupled receptor (PAR-1), as a way to discover the intermolecular contacts interested in agonist peptide reputation. ultimately, bankruptcy 6 describes the study performed at Merck on inhibitors of farnesyl transferase as a possible therapy for human cancers.

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Advances in Medicinal Chemistry: 4 by B. E. Maryanoff,A. B. Reitz


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